Stress produces stem cells in the brain and absence of stress produces neurons-Experience Dictates Stem Cell Fate

in environment, medicine

According to a new study peace of mind is key to the generation of new neurons and  stress leads to the generation of more neuronal progenitor cells, the neural stem cells. 

Scientists from Columbia University report that under stressful conditions, neural stem cells in a specialized brain region called adult hippocampus can produce not only neurons, but also new stem cells. The study demonstrate how environment and experience shape neuronal development and repair.

They observed that deprived and enriched environments had opposite effects. The brains of the socially isolated mice accumulated neural stem cells but not neurons. The brains of mice housed in enriched environments produced far more neurons, but not more stem cells. The average mouse dentate gyrus, the area of the hippocampus where neurogenesis takes place, has about 500,000 neurons; the enriched environment caused an increase of about 70,000 neurons. 

The findings were published online in Neuron on June 9, 2011.

Scientists have known for years that neurogenesis takes place throughout adulthood in the hippocampus of the mammalian brain.

The study results also show that hippocampus adapts to environmental stresses; also, the knowledge of how neural stem cells produce neurons could lead to potential treatment for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.

In Alzheimer's disease, the hippocampus is one of the first regions of the brain to suffer damage. Memory problems and disorientation are among the first symptoms. The hippocampus is involved in memory, learning, and emotion. A research team led by Alex Dranovsky, MD, PhD, assistant professor of clinical psychiatry at Columbia University Medical Center and research scientist in the Division of Integrative Neuroscience at the New York State Psychiatric Institute/Columbia Psychiatry, compared the generation of neural stem cells and neurons in mice housed in isolation and in mice housed in enriched environments. They then used lineage studies, a technique that traces stem cells from their formation to their eventual differentiation into specific cell types, to see what proportion of neural stem cells produced neurons.

"We already knew that enriching environments are neurogenic, but ours is the first report that neural stem cells, currently thought of as 'quiescent,' can accumulate in the live animal," said Dr. Dranovsky. "Since this was revealed simply by changing the animal's living conditions, we think that it is an adaptation to stressful environments. When conditions turn more favorable, the stockpiled stem cells have the opportunity to produce more neurons—a form of 'neurons on demand.'"

The researchers also looked at neuronal survival. They found that social isolation did not cause it to decrease. Scientists already knew that environmental enrichment increased neuronal survival?further increasing the neuron population.

To a lesser extent, location within the hippocampus affected whether stem cells became neurons. While the ratio of stem cells to neurons remained constant in the lower blade of the dentrate gyrus, it varied in the upper blade.

Age also affected the results. After three months, the brains of the isolated mice stopped accumulating neural stem cells. But the mice in enriched environments continued to produce more neurons.

Dranovsky and his team now want to see whether this hippocampal response is specific to social isolation or is a more general response to stress. Another question is whether all neural stem cells have the same potential to produce neurons.

"The long-term goal." Said Dr. Dranovsky, "is to figure out how to instruct neural stem cells to produce neurons or more stem cells. This could lead to the eventual use of stem cells in neuronal replacement therapy for neurodegenerative diseases and other central nervous system conditions."

Source article: Experience Dictates Stem Cell Fate in the Adult Hippocampus. Dranovsky, Alyssa M. Picchini, Tiffany Moadel, Alexander C. Sisti, Atsushi Yamada, Shioko Kimura, E. David Leonardo, and Rene Hen. Neuron Volume 70, Issue 5, 908-923, 9 June 2011. doi.10.1016/j.neuron.2011.05.022.



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