Bringing Light to Born Blind-Project Prakash Answers William Molyneux Question

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If a person born blind gets his eyesight restored in the adulthood will he be able to immediately visually distinguish between objects that he could previously identify by touch?  The studies of Dr Pawan Sinha at MIT, who leads the Project Prakash, does not have an affirmative answer. 

This was the same famous unsolved question asked by scientist William Molyneux  300 years ago and Dr Sinha has an answer now. However, it is not as pessimistic as it appears for those born blind.

The study by Dr Sinha was published in the recent issue of Nature Neuroscience. Dr Sinha started Project Prakash (Prakash means light in Sanskrit) several years ago in the hope of restoring eye sight to the poor in some part of India and simultaneously answering some fundamental questions in cognitive neuroscience bringing hope to hundreds of thousands born blind.

In this study of blind patients in India whose sight was restored in late childhood or adolescence, Sinha and his colleagues found that the patients were not immediately able to make the connection between what they saw and what they felt. However, they acquired that skill within days after surgery. 

The findings, which appear in the April 10 online edition of Nature Neuroscience, suggest that the answer to Molyneux’s question is no. The brain does not have an innate ability to connect different types of sensory input; however, it can quickly learn to do so.




'The Sense of Touch,' by Jusepe de Ribera, depicts a blind man holding a marble head in his hands.


Project Prakash is Sinha's ambitious scientific and humanitarian effort to look at how individuals who are born blind and then gain some vision perceive objects and faces. As part of the project, Sinha, who grew up in New Delhi, will fund the cataract operation for some children whose families cannot afford it. He also hopes to educate Indian health care workers on ways to help children who emerge abruptly from a world of darkness into a world of shadows and patterns as they literally learn to see.

Sinha and his colleagues identified research subjects for the study through Project Prakash, an initiative Sinha founded in India with a dual mission: restoring sight to children who have treatable forms of blindness, and investigating how the brain learns to process visual input

Sangeeta lives in a small village near the baking hot city of Ahmadabad in the Indian state of Gujarat. Born blind, she spent the first 12 of her 30 years sitting in a corner of her disabled, poverty-stricken parents' home, moving around only when she could feel her way.

At age 12, her family received a subsidy that paid for an inexpensive surgical procedure that removed her cataracts, giving her limited vision in one eye. With the help of thick-lensed glasses, she sees well enough to work as a maid, supporting her husband, who also has vision problems. Their 4-year-old blind daughter recently had the cataract operation, but is now in an orphanage because her parents cannot afford to care for her.

Sangeeta and her family are a few of the people that Pawan Sinha, assistant professor of brain and cognitive sciences at MIT, met during a seven-week trip to India during the summer of 2003 as part of Project Prakash.

Dr Sinha pursued Project Prakash to find an answer to Molyneux's question using modern techniques, modern medicine and better-evolved information in cognitive neuroscience.

“Ever since then, this has been one of the foremost questions in the philosophy of mind,” says Pawan Sinha, professor in MIT’s Department of Brain and Cognitive Sciences (BCS). However, the question remained only a thought experiment for centuries, as there was no good way to test it — until now.

Most cases of blindness in India are caused by vitamin A deficiency, cataracts, retinal or optical dystrophies, or microphthalmos (poorly developed eyes). About half of these cases are treatable or preventable, but many blind children never receive medical care, especially in rural areas. Since its founding in 2004, Project Prakash has screened more than 24,000 children and treated about 700.

The latest study is a good example of Project Prakash’s dual mission, says Sinha. “These children have been treated and their lives have hopefully been improved, and that has also allowed us to answer a question that scientists have been puzzling about for over three centuries,” he says.

Sinha, who has published several other research papers on Prakash patients, started this study at the suggestion of Richard Held, MIT professor emeritus of brain and cognitive sciences, who is also an author of the paper. Starting with a 2007 trip to India, the researchers tested five patients on the Molyneux question, ranging in age from 8 to 17. Each had been born blind (four with congenital cataracts, one with corneal opacity).

Each subject (who agreed in advance to participate in the study) was tested within 48 hours of surgery, shortly after his or her bandages were removed.

In the first test, the children were shown a novel object made from plastic parts, which was then taken away. Then they were shown two objects and asked to identify the original one. That test establishes that the children can see well enough to identify the relevant properties of the object, and that they understand the task. The patients performed this test with more than 90 percent accuracy. The patients also performed well in a test where they had to identify, by touch alone, an object that they had earlier handled.

Finally, the patients were asked to visually identify an object they had previously held. In those cases, their answers were not much more successful than if they had guessed.

However, when the researchers tested the patients again, in one case just a week later, they showed dramatic improvement in the touch-to-vision test. The children were tested with different objects than those they encountered during the first session, and they did not receive any kind of training between the two sessions.

This rapid improvement was surprising, says Yuri Ostrovsky, a BCS postdoctoral associate and an author of the paper. He points out that many visual tasks, such as face perception, can take six to 12 months to learn after sight is restored.

Making connections

The researchers believe that the brain learns to make connections between different types of sensory input by analyzing the timing of each stimulus. For example, when you look at your cell phone and hear it ring, your brain receives time-synchronized inputs from different senses. “The brain essentially has to look at the time sequence and figure out the correspondence,” Sinha says.

David Somers, associate professor of psychology at Boston University, described the experiment as “very elegant” and said the Project Prakash studies have made valuable contributions to neuroscientists’ understanding of brain development and plasticity (the ability to change in response to sensory information).

“Traditionally in neuroscience, many insights come from misfortune – someone has an accident and suffers brain damage, or a surgery goes wrong,” says Somers, who was not involved in this study. “We’ve had to wait for the brain to break in interesting ways, and then we go in to analyze it. Here, we’ve got the opposite situation.”

In ongoing studies, Sinha and his colleagues are using brain scans to look for brain regions that may be activated by a certain object, no matter what type of sensory information comes into the brain. For example, they can scan a person’s brain while he or she looks at a pattern of lines, and then scan again when the person is given a tactile pattern with a similar set of lines. If any part of the brain responds to both stimuli, it would suggest that that brain region encodes that pattern, regardless of the sensory modality through which it was detected.

The overall goal of the effort is to understand the learning process through which the visual world begins to cohere into meaningful objects and is linked with information from the other senses, says Sinha, adding that Project Prakash provides a unique window onto this developmental process.

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